Publication in Cancer Cell: Targeting BRCA1 and BRCA2 deficiencies with G-quadruplex-interacting compounds

G-quadruplexes are structures formed in nucleic acids by sequences that are rich in guanine. Four guanine bases can associate to form a square planar structure called a guanine tetrad, and two or more guanine tetrads can stack on top of each other to form a G-quadruplex. Enni Markkanen contributed to a recent study published in Cancer Cell showing that compounds that stabilize such G-quadruplex structures provide a promising pharmacologic tool to treat certain cancer cells. A defect in homologous recombination, for example due to mutations in the breast cancer genes BRCA1 or BRCA2, sensitizes cancer cells to G-quadruplex-interacting drugs.

 

Please use the following link to access the article published in Cancer Cell:

http://www.ncbi.nlm.nih.gov/pubmed/26748828