Publication in International Journal of Molecular Sciences: DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer

Psychiatric diseases with neurodevelopmental origins, such as schizophrenia and autism spectrum disorder (ASD), are associated with tremendous socioeconomic burden. Additionally, patients with ASD and schizophrenia often develop a variety of other disturbances, one of which is cancer. A growing body of evidence indicates that polymorphisms in DNA repair genes, which can lead to the accumulation of DNA damage in the central nervous system, are implicated in the aetiopathogenesis of these disorders. Strikingly, DNA repair gene polymorphisms are also implicated in cancer development. Enni Markkanen und Urs Meyer (in collaboration with Grigory Dianov at the University of Oxford) summarize the current evidence on cancer comorbidity in these brain disorders and discuss the putative involvement of oxidative stress, DNA damage and DNA repair in the aetiopathology of ASD and schizophrenia.

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