Daniele Mattei

Ph.D. Daniele Mattei

Postdoctoral Researcher

Phone: +41 44 63 58764

Address: Winterthurerstrasse 260, 8057 Zürich

Room number: TFA 00.55

daniele.mattei@vetpharm.uzh.ch

Curriculum Vitae

 

Name

Daniele Mattei

Born 06th May, 1986, Italy

 

Nationality

Italy

 

Address

Institute of Veterinay Pharmakology and Toxikology

Winterthurerstrasse 260

CH-8057 Zurich

 

 

 

Education and Academic Positions

 

2017 – pres.

 

Post Doc

Institute of Veterinay Pharmakology and Toxikology,

Zurich, Switzerland

Supervised by Prof. Dr. Urs Meyer

 

2012 – 2016

PhD-Student
Max-Delbrück Centrum for Molecular Medicine, Cellular Neuroscience, Lab of Professor Dr. Helmut
Kettenmann, Berlin (Germany)

 

2013

Training abroad
Nencki Institute of Experimental Biology, lab of Professor Bozena Kaminska, Warsaw (Poland)

Training abroad
University of Groningen, Department of Neuroscience, Lab of Professor Dr. Erik H W G M Boddeke, Groningen (Netherlands)

 

2009 - 2011

Trainee researcher
Angelini Pharma, ACRAFspa, Rome (Italy)

Trainee researcher
Department of genetics and molecular biology (Laboratory of Psychobiology), La Sapienza University of Rome, Rome (Italy)

 

2005 – 2010

Master of Science in Molecular Biology with specialization in Medical Biology
University of Lund, Department of Biology, Lund (Sweden)

 

 

Research Interests

 

Maternal immune activation during pregnancy can increase the risk in the offspring to develop mental disorders such as schizophrenia and autism. Maternal immune activation is able to disrupt the normal trajectories of brain development possibly leading to the brain misconnection observed in both autism and schizophrenia. Using animal models of maternal immune activation, Daniele’s research goals are to understand the changes in transcriptional program and hence function that occur in different cell subtypes in the brain of the offspring born from immune challenged dams. Daniele’s particular focus is to uncover the cell and brain region specific transcriptional changes that accompanies the pathological behavioural traits observed in the adult offspring. A particular emphasis is set on microglia cells, the intrinsic immune cells of the CNS. The latter are believed to play a crucial role in the development and maintenance of our brain circuitry and they may prove to be a valuable target for future treatment of neuropsychiatric diseases.

 

 

 

Publications

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment. Daniele Mattei*, Andranik Ivanov*, Carmelo Ferrai, Philipp Jordan, Dilansu Guneykaya, Alice Buonfiglioli, Wandert Schaafsma, Piotr Przanowski, Winnie Deuther-Conrad, Peter Brust, Swen Hesse, Marianne Patt, Osama Sabri, Tobias L Ross, Bart J.L. Eggen, Erik W.G.M. Boddeke, Bozena Kaminska, Dieter Beule, Ana Pombo, Helmut Kettenmann and Susanne A. Wolf.  Translational Psychiatry, 2017.

 

Ly6Chi monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis. Luisa Möhle*, Daniele Mattei*, Markus M.Heimesaat*, Stefan Bereswill, André Fischer, Marie Alutis, Dolores Hambardzumyan, Polly Matzinger, Ildiko R. Dunay and Susanne A. Wolf. Cell Reports, 2016.

Brain in flames – Animal models of schizophrenia: utility and limitations. Mattei D, Schweibold R, Wolf SA. Neuropsychiatric Disease and Treatment, 2015.

Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia. Mattei D*, Djodari-Irani A*, Hadar R, Pelz A, de Cossío LF, Goetz T, Matyash M, Kettenmann H, Winter C, Wolf SA. Brain Behav Immun, 2014.

 Cytokine levels in the blood may distinguish suicide attempters from depressed patients. Janelidze